Prof Werner Muller

Werner Muller – Research summary

Prof Werner Muller

Prof Werner Muller

My research group studies the cellular cytokine network, cell adhesion and Immunogenetics.

Cytokines are small molecules regulating the immune system. We aim to find out which cells are producing cytokines and which cells respond to cytokines in normal conditions and in diseases. Our main focus in on diseases related to chronic inflammation.

Chronic inflammation is often associated in changes in cell adhesion molecules. By generating and analyzing mouse models deficient for cell adhesion molecules we are able to define the role of these molecules.

Immunogenetics studies the evolution of molecules which have evolved as essential components of the immune system. We are particularly interested in antibody genes and have generated expert databases and software for antibody gene analyses.

Our major contributions have been in three areas:

1. Defining the role of cytokines for the Immune system

By inactivating cytokine or receptor genes we are able to define the in vivo function of cytokines. By conditional ablation of cytokine or cytokine receptor genes we are able to analyse the cellular contribution to cytokine networks.

Science, 254, 707-10. (1991).  Cell, 75(2), 263-74. (1993). J exp med, 188, 1955-65 (1998).

2. Understanding the role of adhesion molecules for the gut associated system

By inactivating adhesion molecules we are able to identify key molecules for the proper development of the gut associated immune system.

Nature, 382, 366-70 (1996). Gastroenterology, 137, 924-933 (2009).

3. Developing tools for the analysis of antibody genes

We developed an Immunoglobulin V gene database, called VBASE2 and generated tools associated with the database in order to analyse antibody genes.

Nucleic Acids Research, 33, D671-4 (2005). J Immunol, 179, 2419-27 (2007).

Email: werner.muller@manchester.ac.uk Tel: 0161 275 5233

People

Werner Muller – People

Catherine Walker (Postdoc)
Shuangmin Gao (PhD student)
Ryan Costello (PhD student)
Sayema Rahman (Research technician)
Rajesh Patha (Volunteer)

Previous lab members

PhD students
Masih-ul Alam
Brook Cooper

People

Werner Muller – People

Catherine Walker (Postdoc)
Shuangmin Gao (PhD student)
Ryan Costello (PhD student)
Sayema Rahman (Research technician)
Rajesh Patha (Volunteer)

Previous lab members

PhD students
Masih-ul Alam
Brook Cooper

Biography

In 1981 I obtained a Diploma Degree in Biology, specialized in Genetics at the Institute for Genetics, University of Cologne. In 1987 I received a doctorial degree (Dr. rer. nat.) from the University of Cologne. In 2000 I moved to a big research centre in Braunschweig, now named the Helmholtz Centre for Infection research, opening a new department of experimental Immunology. In 2006 I became the Bill Ford Chair of Cellular Immunology at The University of Manchester.

See my Faculty profile for more information.